I just finished "Running with Scissors" by Augusten Burroughs and its sequel "Dirt." (Thanks to Michael for mentioning the latter.)
"Scissors" is disturbing, funny, and dark. It's already been made into a movie which didn't get great reviews, I understand. "Scissors" was on the NYT best-seller list for 2 years. However, the family in "Scissors" (the Finches) is a thinly disguised version of the real life Turcotte family who filed a lawsuit in 2005 against Burroughs and the book's publisher, St. Martin, for invasion of privacy and libel. The January Vanity Fair has a lengthy, fascinating article about the whole thing.
"Dirt" is a horrendous account of the 26 year old Burroughs as an alcoholic ad man in Manhattan and his problems with addiction, holding his job, his lover, and coming to grips with it all. It's a very sad, gut-wrenching account, and I found myself pulling for Burroughs and heart-broken over his best friend who has HIV. In spite of the horrendous childhood, Burroughs suffered through in "Scissors," "Dirt" is darker and even more gut-wrenching,to me, but both books will stay with the reader for a long time.
BTW, Michael, both of these books could be likely candidates for future book club selections.