I very much enjoyed Transamerica (which I first in September at the Toronto film festival), and hope others do, too.
I want to see The Dying Gaul (which hasn't opened here yet), Glory Road (a basketball film with Josh Lucas), Imagine Me & You (British lesbian rom-com, the trailer for which I saw at a BBM screening), The Three Burials of Melquiades Estrada, Match Point, Cache (French film which I've heard is very good).
In the further future I'm looking forward to the new Almodovar film, Volver, with Penelope Cruz. And, as a pulp film, I'd like to see The DaVinci Code.