As an historical note: when the New Testament canon was being decided, in the 4th century A.D., the Eastern Church wanted Revelations excluded. The Church of Rome required its inclusion, as the general interpretation, at that time, was that it was a coded account of the 500,000 to 1,000,000 victims of the Roman Empire's long persecution.
As a further note, both Rome and Jerusalem are the 2 cities that have serious problems in excavating for laying foundations for new buildings. History is everywhere they dig. In Rome, in the 20th century, they kept running into mass graves of Christians, hence the upwards revision of how many were slaughtered. It was....genocide.
Now, of course, various cults use the book to refer to the Church of Rome as the Whore of Babylon. Neat reversal of the original context. The victim of the Roman Empire, the church, is now the villain.